Myc癌蛋白家族(C-、N-、L-myc)是一类序列特异的转录因子,参与细胞生长、分化及细胞程序性死亡的调节。其表达的失调显然能通过一种共同的遗传途径或者共享的遗传元件,影响培养细胞及转基因小鼠的恶变。虽然它们各成员间的结构和功能类似,但仍各具不同的生理功能。目前已知Myc家族基因在发育的早期功能重迭,而后期则否。 Myc oncoprotein family (C-, N-, L-myc) is a family of sequence-specific transcription factors that are involved in the regulation of cell growth, differentiation and apoptosis. Deregulation of its expression apparently affects malignant changes in cultured cells and transgenic mice via a common genetic pathway or shared genetic elements. Although their structure and function are similar among members, they still have different physiological functions. It is known that the Myc family genes overlap functionally in the early stages of development, but not later.