Reliability and optimization are two key elements for structural design. The reliabilitybased topology optimization(RBTO) is a powerful and promising methodology for finding the optimum topologies with the uncertainties being explicitly considered, typically manifested by the use of reliability constraints. Generally, a direct integration of reliability concept and topology optimization may lead to computational difficulties. In view of this fact, three methodologies have been presented in this study, including the double-loop approach(the performance measure approach, PMA) and the decoupled approaches(the so-called Hybrid method and the sequential optimization and reliability assessment, SORA). For reliability analysis, the stochastic response surface method(SRSM) was applied, combining with the design of experiments generated by the sparse grid method, which has been proven as an effective and special discretization technique.The methodologies were investigated with three numerical examples considering the uncertainties including material properties and external loads. The optimal topologies obtained using the deterministic, RBTOs were compared with one another; and useful conclusions regarding validity,accuracy and efficiency were drawn. Reliability and optimization are two key elements for structural design. The reliabilitybased topology optimization (RBTO) is a powerful and promising methodology for finding the optimum topologies with the uncertainties being explicitly considered. of reliability concept and topology optimization may lead to computational difficulties. In view of this fact, three methodologies have been presented in this study, including the double-loop approach (the performance measure approach, PMA) and the decoupled approaches (the so-called Hybrid method and the sequential optimization and reliability assessment, SORA). For reliability analysis, the stochastic response surface method (SRSM) was applied, combining with the design of experiments produced by the sparse grid method, which has been proven as an effective and special discretization technique. methodologies were investigated with three numerical e The optimal topologies obtained using the deterministic, RBTOs were compared with one another; and useful records regarding validity, accuracy and efficiency were drawn.