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目的探讨 CD40L 单因子诱导成人急性淋巴细胞性白血病(aALL)细胞成为树突状细胞(DC)的可行性,并观察这种白血病来源的 DC 体外活化 T 细胞的能力。方法分离 aAL 初治患者骨髓液中单个核细胞(BMMNC)。将0.5μg/mL、1.5μg/mL、3μg/mL CD40L 单因子,加入接种
Objective To investigate the feasibility of using CD40L as a single factor to induce adult acute lymphoblastic leukemia (aALL) cells to become dendritic cells (DCs) and to observe the ability of DC derived from these leukemias to activate T cells in vitro. Methods Mononuclear cells (BMMNC) from bone marrow of patients with aAL untreated were isolated. 0.5 μg / mL, 1.5 μg / mL, 3 μg / mL CD40L single factor was added for inoculation