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肝细胞癌(HCC)的发生与多种因素有关。早期的流行病学研究显示非洲人群饮食中铁过量与HCC发生相关,继而研究发现许多与铁沉积相关的疾病如遗传性血色素沉积症(HH)、丙型病毒性肝炎、非酒精性脂肪性肝病(NAFLD)等在发展过程中均有发生HCC的可能性,提示铁超载可能在其中发挥着直接或间接的作用。现认为铁超载的发生与基因突变、铁代谢相关基因蛋白的异常表达、氧化应激反应、免疫紊乱、促进癌细胞生长等因素有关。本文就铁超载与HCC的相关研究现状作一综述。
The occurrence of hepatocellular carcinoma (HCC) is related to many factors. Early epidemiological studies have shown that iron overload in the diet of African populations is associated with HCC, followed by studies that found many iron deposition-related diseases such as hereditary hemochromatosis (HH), hepatitis C virus, non-alcoholic fatty liver disease NAFLD) in the development process are likely to occur HCC, suggesting that iron overload may play a direct or indirect role. Now that the occurrence of iron overload and genetic mutations, iron metabolism-related gene protein abnormal expression, oxidative stress response, immune disorders, and promote cancer cell growth and other factors. This article reviews the related research status of iron overload and HCC.