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目的探讨PON1基因Q192R位点在广西巴马地区不同人群中的频率及PON1基因多态性与巴马地区长寿现象的相关性。方法采用TaqMan探针实时荧光PCR技术对广西巴马长寿地区123例长寿老人(年龄90岁以上,长寿组)以及巴马长寿地区138例无长寿史的健康成年人(年龄24～87岁,对照1组)、巴马非长寿地区147例无长寿史的健康成年人(年龄48～89岁,对照2组)和南丹地区144例无长寿史的健康成年人(年龄21～83岁,对照3组)的PON1基因进行基因分型。结果长寿组与各对照组比较,等位基因和基因型分布差异存在统计学意义(P<0.05)。结论该多态性位点与地域有关,与巴马长寿地区的长寿现象是否有关还需进一步验证。
Objective To investigate the frequency of P19 gene in PON1 gene and its association with PON1 gene polymorphism in different populations of Bama region in Guangxi province and the longevity in Bama region. Methods One hundred and thirty-three healthy adults (aged 24-87 years) with longevity were enrolled in this study. One hundred and thirty-three longevity old people (aged over 90 years old and longevity group) in Changshou area of Bama in Guangxi province and 138 healthy longevity people 1 group), 147 healthy adults without long life history (aged 48-89 years, control group 2) and 144 healthy adults without long life history (aged 21-83 years) in Nandan district in non-prolonged Bama district. 3 groups) of PON1 gene for genotyping. Results There were significant differences in allele and genotype distribution between longevity group and control groups (P <0.05). Conclusion The polymorphism loci are related to the region, and whether the longevity phenomenon in the longevity area of Bama needs to be further verified.