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随着核工业的迅速发展,核燃料铀对人类构成了一种潜在威脅。铀在人体脏器内的沉积不但引起损伤,并能诱发肿瘤。关于铀的促排解毒药物,虽有一些报道,但未见在临床应用。作者等曾合成了多个系列新的膦酸类和邻苯二酚类双取代或单取代胺羧酰胺螫合剂,动物试验结果表明其中的大多数排铀效果显著,尤其是邻苯二酚类单取代胺羧酰胺(Ⅰ)中,若干化合物排铀效果远远超过文献报道较多的钛铁试剂和Phosphicine,而且显示了
With the rapid development of the nuclear industry, nuclear fuel uranium poses a potential threat to human beings. Deposition of uranium in human organs not only causes damage but also induces tumors. Uranium on the anti-detoxification drugs, although some reports, but no clinical application. The authors have synthesized a series of new series of phosphonic acid and catechol disubstituted or mono-substituted amine carboxamide chelating agent, the animal test results show that most of them have a significant effect of uranium emission, especially catechols Mono-substituted amine carboxamide (Ⅰ), a number of compounds uranium emission effect far more than reported in the literature more iron and titanium reagents and Phosphicine, but also shows