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目的观察来氟米特联合泼尼松治疗难治性肾病综合征的疗效及安全性。方法 58例难治性肾病综合征患者,给予来氟米特联合泼尼松治疗,观察治疗前、治疗后2周~6个月的24 h尿蛋白定量、血清白蛋白、血肌酐的变化,并观察药物的不良反应。结果治疗6个月后完全缓解25例,部分缓解20例,无效10例,复发3例,有效率为77.59%。出现胃肠道症状3例,肝功能轻微受损2例,白细胞减少2例。结论来氟米特联合泼尼松对大部分难治性肾病综合征有效且安全。
Objective To observe the efficacy and safety of leflunomide combined with prednisone in the treatment of refractory nephrotic syndrome. Methods Fifty - eight patients with refractory nephrotic syndrome were treated with leflunomide and prednisone. The 24 - hour urinary protein, serum albumin and serum creatinine were measured before and after treatment for two weeks to six months. And observe the adverse drug reactions. Results After 6 months of treatment, complete remission was achieved in 25 cases, partial remission in 20 cases, ineffective in 10 cases and recurrence in 3 cases. The effective rate was 77.59%. Gastrointestinal symptoms occurred in 3 cases, 2 cases of mild liver damage, leukopenia in 2 cases. Conclusion Leflunomide combined with prednisone is effective and safe for most refractory nephrotic syndromes.