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目的评价小剂量螺内酯联合美托洛尔治疗慢性心力衰竭的疗效。方法将本院68例慢性心力衰竭患者随机分成试验组与对照组各34例。对照组采用基础治疗加服美托洛尔,试验组加载螺内酯联用美托洛尔治疗。分别在入组前、用药4个疗程后按NYHA心功能分级标准评估两组患者心功能分级变化,采用化学发光法检测NT-proBNP值并对患者进行心脏彩超检查记录左心室射血分数(以下称射血分数,EF)。结果治疗4个疗程后,试验组的心功能显效率和总有效率显著高于对照组(P<0.05);相比于治疗前两组的射血分数均显著升高,而NT-proBNP大幅下降,4个月后试验组血清NT-proBNP显著低于对照组,心脏射血分数略高于对照组。结论螺内酯联合美托洛尔能有效提高美托洛尔治疗慢性心力衰竭的疗效。
Objective To evaluate the efficacy of low-dose spironolactone combined with metoprolol in the treatment of chronic heart failure. Methods 68 cases of chronic heart failure patients were randomly divided into experimental group and control group of 34 cases. The control group received basic treatment plus metoprolol, and the experimental group received spironolactone plus metoprolol. The levels of NT-proBNP were measured by chemiluminescence and the left ventricular ejection fraction was recorded by echocardiography after the 4 courses of treatment according to NYHA functional classification criteria before enrollment. Said ejection fraction, EF). Results After 4 courses of treatment, the markedly effective rate and total effective rate of cardiac function in the experimental group were significantly higher than those in the control group (P <0.05). Compared with the two groups before treatment, the ejection fraction was significantly increased, while NT-proBNP significantly After 4 months, the serum NT-proBNP in the experimental group was significantly lower than that in the control group. The ejection fraction of the heart was slightly higher than that of the control group. Conclusion Spironolactone combined with metoprolol can effectively improve the efficacy of metoprolol in the treatment of chronic heart failure.