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为了观察金龙胶囊联合同步放化疗(CCRT)治疗中晚期鼻咽鳞癌的临床疗效和毒副反应,将97例中晚期鼻咽鳞癌患者随机分为治疗组(Ⅰ组)49例和对照组(Ⅱ组)48例。Ⅰ组应用金龙胶囊联合CCRT,金龙胶囊4粒/次,3次/d,连服3个月。Ⅱ组仅行CCRT。观察近期疗效、局部皮肤黏膜损伤及治疗前后体质量、Karnosfsky评分变化。治疗组有1例患者因心肌梗死退出,对照组1例因黏膜毒性退出。治疗后、结束后4周及治疗后12周的CR率Ⅰ组均较Ⅱ组高,差异无统计学意义,P>0.05;金龙胶囊明显减轻治疗组的不良反应,对预防皮肤黏膜炎差异有统计学意义。两组患者治疗结束后12周口干发生率差异及治疗结束后Karnosfsky评分差异均无统计学意义,P>0.05。结束后第4周和第12周,Ⅰ组和Ⅱ组患者体质量下降差异有统计学意义(P值分别为0.04和0.023)。初步研究结果提示,金龙胶囊联合CCRT治疗中晚期鼻咽鳞癌临床疗效显著,可显著降低放化疗毒副反应,改善生活质量。
In order to observe the curative effect and toxicity of Jinlong Capsule combined with concurrent chemoradiotherapy (CCRT) on advanced nasopharyngeal squamous cell carcinoma, 97 patients with advanced nasopharyngeal squamous cell carcinoma were randomly divided into treatment group (Ⅰ group) and control group (Group Ⅱ) 48 cases. Group Ⅰ Jinlong capsule combined with CCRT, Jinlong capsule 4 capsules / time, 3 times / d, and even for 3 months. Group Ⅱ only CCRT. Observation of short-term curative effect, local skin and mucosal injury and body mass before and after treatment, Karnosfsky score changes. One patient in the treatment group withdrew due to myocardial infarction and one patient in the control group withdrew due to mucosal toxicity. After treatment, 4 weeks after the end and 12 weeks after the CR rate Ⅰ group were higher than the Ⅱ group, the difference was not statistically significant, P> 0.05; Jinlong capsule significantly reduce the adverse reactions in the treatment group, the prevention of skin mucositis differences Statistical significance. There was no significant difference in the incidence of dry mouth between the two groups at 12 weeks after treatment and Karnosfsky score after treatment (P> 0.05). At 4 weeks and 12 weeks after the end, there was significant difference in body weight between group I and group II (P = 0.04 and 0.023, respectively). Preliminary results suggest that Jinlong Capsule combined with CCRT in the treatment of advanced nasopharyngeal squamous cell carcinoma clinical significant effect, can significantly reduce the radiotherapy and chemotherapy side effects and improve quality of life.