论文部分内容阅读
观察了大鼠面神经后核内侧区（ｍＮＲＦ）微量注射两种不同氨基酸类递质对呼吸的影响。结果如下：１．ｍＲＮＦ区注射－氨基丁酸（ＧＡ－ＢＡ），呼吸频率和膈肌放电积分幅值下降，每分膈肌电活动减小，部分动物出现呼吸暂停。预先注射荷包牡丹硷（Ｂｉｃｕｃｕｌｉｎｅ）后，可拮抗由ＧＡ－ＢＡ所引起的呼吸抑制效应。２．ｍＮＲＦ注射Ｌ－谷氨酸单钠（Ｌ－ｇｌｕｔａｍａｔｅｍｏｎｏｓｏｄｉｕｍ），呼吸频率增加，每分隔肌电活动明显增加，ＡＰ－７可阻断谷氨酸的呼吸效应。此结果提示，ＧＡＢＡ和谷氨酸可能作为抑制或兴奋性递质作用于ｍＮＲＦ区的神经元而发挥呼吸调节作用
The effect of two different amino acid neurotransmitters microinjected into the medial area of the posterior facial nucleus of the facial nerve (mNRF) on the respiration was observed. The results are as follows: 1. In the mRNF area, GA-BA was injected. The respiratory rate and the amplitude of the diaphragm discharge were decreased. The electrical activity per diaphragm was decreased. Some animals showed apnea. Pre-injection of bicuculline (Bicuculine) antagonized the respiratory depression caused by GA-BA. 2. mNRF injection of L-glutamatemonosodium, respiratory rate increased, each separated significantly increased myoelectric activity, AP-7 can block the respiratory effects of glutamate. This result suggests that GABA and glutamate may play respiratory modulatory roles in neurons of the mNRF region as inhibitory or excitatory neurotransmitters