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亚硫酸氢钠胡椒酮是由芸香草[Cymbopogon dis-tans(Nees.)A.Camus]的茎叶经水蒸气蒸馏而得挥发油,再经亚硫酸氢钠与挥发油中胡椒酮(Ⅰ)加成反应提取后浓缩制得的水溶性白色鳞片状结晶。自1969年以来由我区绵阳制药厂生产和制成片剂,用以治疗支气管哮喘和慢性支气管炎。关于纯亚硫酸氢钠胡椒酮的理化性状和结构式未见报导,仅见应用亚硫酸氢钠法测定和分离挥发油中胡椒酮。以往我所根据碱解后用酸回滴定和碱解后碘量法测定含量计算,亚硫酸氢钠与胡椒酮的克分子数比接近1:1,故其可能的结构式为Ⅱ或Ⅲ,
Sodium bisulfite is a volatile oil derived from the steam distillation of stems and leaves of Cymbopogon dis-tans (Nees. A.Camus). Sodium bisulfite is added with piperonyl ketones (I) in the volatile oil After the reaction was concentrated to obtain a water-soluble white flaky crystals. Since 1969 Mianyang Pharmaceutical Factory in our region produced and made tablets for the treatment of bronchial asthma and chronic bronchitis. About pure sodium bisulfite piperonyl physical and chemical properties and structural formula has not been reported, only the application of sodium bisulfite method for the determination and separation of the volatile oil piperonyl. In the past, according to the alkali solution after acid back titration and alkali content after iodometric determination, sodium bisulfite and piperonyl molar ratio close to 1: 1, so the possible structural formula Ⅱ or Ⅲ,