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研究者在一个纵向家庭研究中以单标记和新基因为基础的方法探讨内皮系统基因与血压改变和高血压发病率的关系。方法:盐敏感性的遗传流行病学随访研究共纳入633个汉族家庭的1768位成员。使用随机零点血压计,获取基线和随访调查的共9次血压值。应用混合效应模型来评估15个内皮系统基因中的206个单核苷酸多态性(SNPs)与纵向血压改变及高
In a longitudinal family study, the authors used single-marker and novel gene-based approaches to explore the relationship between endothelial system genes and changes in blood pressure and the incidence of hypertension. METHODS: A salt-sensitive genetic epidemiological follow-up study enrolled 1768 members of 633 Han families. Using a random zero sphygmomanometer, a total of 9 blood pressure values were obtained for baseline and follow-up surveys. The mixed-effects model was used to assess 206 single nucleotide polymorphisms (SNPs) in the 15 endothelial system genes and longitudinal blood pressure changes and high