论文部分内容阅读
①目的探讨β－内啡肽（β－ＥＮＤ）对大鼠血浆唾液酸（ＳＡ）水平的影响。②方法在Ｗｉｓｔａｒ大鼠侧脑室分别注射浓度为２５，５０和１００μｍｏｌ／Ｌ的β－ＥＮＤ（生理盐水对照）和抗β－ＥＮＤ血清（正常兔血清对照），注射前及注射后５，１５，２５和３５ｍｉｎ分别取血，紫外分光光度仪测ＳＡ含量。③结果注射β－ＥＮＤ后大鼠血浆ＳＡ水平较注射前均降低，并且随β－ＥＮＤ浓度的增加，ＳＡ水平降低所需的时间逐渐缩短；注射抗β－ＥＮＤ血清后大鼠血浆ＳＡ水平较注射前升高。④结论外源性及内源性的β－ＥＮＤ均参与了降低大鼠血浆ＳＡ水平的调节过程，并且呈一定的量效依赖关系。
Objective To investigate the effect of β-endorphin (β-END) on plasma sialic acid (SA) in rats. ② Methods Wistar rats were injected intracerebroventricularly with β-END (25, 50 and 100 μmol / L) and anti-β-END serum (normal rabbit serum) 25 and 35min were taken blood, UV spectrophotometry SA content. Results The levels of plasma SA in rats after β-END injection decreased compared with those before injection, and the time required for the reduction of SA level was gradually decreased with the increase of β-END concentration. The levels of SA in plasma after anti-β-END serum injection Elevated before injection. ④ Conclusion Exogenous and endogenous β-END are involved in the regulation of plasma SA levels in rats, and showed a certain dose-effect relationship.