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自1975年Kohler和Milstein首先应用淋巴细胞杂交瘤技术取得特异性单克隆抗体以来,单克隆抗体的应用,已成为医学上一个热门的新课题。在肿瘤研究方面,应用单克隆抗体不仅可鉴定肿瘤特异性抗原,探讨肿瘤抗原的化学和生物学特征,用于肿瘤特异性免疫诊断,而且已有直接用单克隆抗体作为被动免疫治疗白血病和淋巴瘤的报道。用单克隆抗体治疗肿瘤虽然取得了一定成绩,但目前还存在一些限制单克隆
Since 1975, Kohler and Milstein first application of lymphocyte hybridoma technology to obtain specific monoclonal antibodies, the application of monoclonal antibodies, has become a hot new topic in medicine. In the field of oncology, the use of monoclonal antibodies not only identifies tumor-specific antigens, discusses the chemical and biological characteristics of tumor antigens, and is used in tumor-specific immunodiagnostics, but monoclonal antibodies have also been used directly as passive immunotherapy for leukemias and lymphomas Report of the tumor. Although there have been some achievements in the treatment of tumors with monoclonal antibodies, there are still some limitations on monoclonal