自体骨髓移植(Autologous Bone Ma-rrow Transplantation,AB MT)作为治疗肿瘤性疾病,特别是血液系统恶性肿瘤提高化疗、放疗疗效,达到根治或更好地控制疾病的目的,近十多年已取得一定进展。由于供移植用骨髓系采自病人,骨髓内含有一定量的瘤细胞,回输这些未经处理的瘤细胞会使肿瘤复发而大大降低ABMT的应用效果。如何在回输前从骨髓内清除这些瘤细胞已成为研究的重点。试用于清除瘤细胞的方法有多种,本文就以单克隆抗体(McAb)的广泛应用,作一综述。单克隆抗体(McAb)与补体原理:是利用特异的McAb结合残留的瘤细胞,加入补体使产生细胞毒以溶解瘤细胞,早在1977年Thierfelder等就利用抗T胸腺细 Autologous bone marrow transplantation (Autologous Bone Matrine Transplantation, AB MT) for the treatment of neoplastic diseases, especially hematological malignancies to improve the efficacy of chemotherapy, radiotherapy, to achieve radical or better control of the disease, the past decade has achieved certain progress. Since the bone marrow for transplantation is collected from the patient, the bone marrow contains a certain amount of tumor cells, and the reintroduction of these untreated tumor cells can make the tumor recur and greatly reduce the application effect of ABMT. How to remove these tumor cells from bone marrow before reinfusion has become the focus of research. Try to clear the tumor cells in a variety of ways, this article on the monoclonal antibody (McAb) is widely used, for a review. Monoclonal antibody (McAb) and complement principle: the use of specific McAb binding residual tumor cells, adding complement to produce cytotoxic to lyse tumor cells, as early as 1977, Thierfelder and other anti-T thymus fine