白喉是由白喉棒状杆菌引起的急性呼吸道传染病,是中国免疫规划重点预防控制传染病之一。随着疫苗的应用,尤其是计划免疫的实施,免疫接种的规范化、科学化和系统化,百白破混合制剂(DPT)免疫覆盖率的逐步提高,中国白喉得到了很好的控制,发病率和死亡率显著下降〔1〕。为了解海南省儿童百白破疫苗和白破疫苗接种质量和免疫效果,本研究 Diphtheria is an acute respiratory infection caused by Corynebacterium diphtheria and one of the key prevention and control infectious diseases in China’s immunization program. With the application of vaccines, especially the implementation of planned immunization, the standardization, scientific and systematic immunization, the gradual increase of immunization coverage of DPT, the Chinese diphtheria has been well controlled and the incidence rate And mortality decreased significantly 〔1〕. In order to understand the quality and immune effect of Baitiao broken vaccine and Baishuai vaccine in Hainan province, this study