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“归巢”理论认为乳腺癌的转移是一个主动、有序、有器官选择性的过程,其中特异性趋化因子受体4(CXCR4)和趋化因子配体12(CXCL12)所构成的生物学轴在乳腺癌器官特异性转移中发挥重要作用,本文就该轴与乳腺癌转移的临床试验和动物实验研究及其发挥作用机理的研究进展作一综述。
“Homing” theory suggests that breast cancer metastasis is an active, orderly, and organ-selective process in which organisms consisting of specific chemokine receptor 4 (CXCR4) and chemokine ligand 12 (CXCL12) Axis plays an important role in the organ-specific metastasis of breast cancer. This review summarizes the clinical and experimental studies on the mechanism of axonal and breast cancer metastasis and its mechanism of action.