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目的:探讨饮酒与子宫内膜异位症发病风险的关系。方法:采用以人群为基础的病例对照研究,调查石家庄市2004年1月~2013年12月年龄30~49岁的子宫内膜异位症患者和绝经前育龄妇女的一般情况、受教育程度、经济状况、家族史、婚姻状况、月经生育史、避孕方法,发育史和身体测量等资料,采用非条件Logistic回归模型分析饮酒与子宫内膜异位症的关系。结果:与从未饮酒者相比,饮酒者子宫内膜异位症发病风险增高(OR=2.01,95%CI:1.12~4.51,P<0.01);与从未饮酒者为参比组,开始饮酒年龄≥30岁及<30岁组的OR分别为1.33(95%CI:0.92~2.39)和2.05(95%CI:1.38~3.96),提示饮酒年龄与子宫内膜异位症的发病有关(P=0.008);将被调查对象按照饮酒年限中位数分组,与从未饮酒者相比,饮酒年限≤13和>13年者的OR值分别为1.65(95%CI:1.21~2.29)和2.67(95%CI:1.29~3.12);将被调查对象按照每周饮酒次数中位数分组,与从未饮酒者相比,每周饮酒次数≤3和>3的OR值分别为0.89(95%CI:0.29~1.00)和5.79(95%CI:3.21~6.85);而非大量饮酒、每周饮酒次数≤3的被调查对象的子宫内膜异位症的发病率与从未饮酒者比较无统计学意义(P>0.05)。结论:大量饮酒(>113.1 g/次)可能是子宫内膜异位症的危险因素。
Objective: To explore the relationship between alcohol consumption and the risk of endometriosis. Methods: A population-based case-control study was conducted to investigate the general situation of endometriosis patients and premenopausal women of childbearing age between the ages of 30 and 49 in Shijiazhuang from January 2004 to December 2013. The educational level, Economic status, family history, marital status, menstrual history of birth, methods of contraception, developmental history and physical measurements and other data, the use of non-conditional Logistic regression model analysis of alcohol and endometriosis relationship. Results: Compared with never-drinkers, drinkers had a higher risk of endometriosis (OR = 2.01, 95% CI: 1.12-4.51, P <0.01) OR of 1.33 (95% CI: 0.92-2.39) and 2.05 (95% CI: 1.38-3.96), respectively, for alcohol consumption ≥30 years and <30 years old, suggesting that drinking age was associated with the onset of endometriosis P = 0.008). The odds ratio (OR) of subjects with ≤13 and> 13 years of drinking were 1.65 (95% CI: 1.21-2.29) and 2.67 (95% CI: 1.29 ~ 3.12). The ORs of subjects were grouped according to the median of weekly drinking times, and the odds of ≤3 and> 3 weekly drinking were 0.89 (95 % CI: 0.29-1.00), and 5.79 (95% CI: 3.21-6.85). The incidence of endometriosis in the surveyed subjects who did not drink in large quantities and whose drinking frequency was less than 3 per week was significantly lower than that in never-drinkers No statistical significance (P> 0.05). Conclusion: Drinking alcohol in large quantities (> 113.1 g / time) may be a risk factor for endometriosis.