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为研究饮酒、吸烟与子宫内膜癌的关系,开始于1986年的荷兰队列研究,以自我检测问卷方式调查了62573名妇女的饮食习惯以及其他的癌症危险因素的暴露情况。经过11.3年的随访,共有280名子宫内膜癌患者可供分析。经多因素分析,饮酒者相对于不饮酒者的RR为1.06(95%CI:0.78~1.43),并且所有类型的酒精饮料和子宫内膜癌之间都没有关联,也不存在剂量-反应关系。曾经吸烟和当前吸烟相对于非吸烟者的RR分别为0.83(95%CI:0.58~1.20)和0.59(95%CI:0.40~0.88)。当把体重指数和绝经年龄加入分析模型后结果没有显著改变。研究认为,饮酒和子宫内膜癌之间没有关联;当前吸烟能降低子宫内膜癌的发病危险。这种关联不受体重指数和绝经年龄的影响。
To study the relationship between alcohol consumption and smoking and endometrial cancer, a Dutch cohort study was started in 1986 to investigate the dietary habits of 62,573 women and other cancer risk factors using a self-administered questionnaire. After 11.3 years of follow-up, a total of 280 patients with endometrial cancer are available for analysis. On a multivariate analysis, RR was 1.06 (95% CI: 0.78 to 1.43) for drinkers versus non-drinkers, and there was no association between all alcoholic drinks and endometrial cancer and no dose-response relationship . The RRs of former and current smokers relative to non-smokers were 0.83 (95% CI: 0.58-1.20) and 0.59 (95% CI: 0.40-0.88), respectively. The results did not change significantly when body mass index and menopausal age were added to the analysis model. Studies suggest that there is no association between drinking alcohol and endometrial cancer; current smoking can reduce the risk of endometrial cancer. This association is not affected by body mass index and menopausal age.