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IL-2Rα不仅在细胞表面,而且在T 细胞培养上清和成人T 细胞白血病患者血清中也能检出。可溶性IL-2Rα(SIL-2Rα)在胶原病患者血清和慢性风湿性关节炎(RA)患者关节液中含量较高。如果SIL-2Rα值在早期RA 也升高,则对于确定可疑为RA患者的诊断和治疗方针有重要意义。实验测定了初诊时尚不能确诊的RA 患者血清SIL-2Rα,并观察患者以后的病情变化。研究初诊时SIL-2Rα浓度与一年后病情的关系。
IL-2Rα is detected not only on the cell surface, but also in the serum of T cell culture supernatant and adult T-cell leukemia patients. Soluble IL-2Rα (SIL-2Rα) is found in synovial fluid in patients with collagen disease and in patients with chronic rheumatoid arthritis (RA). If SIL-2Rα values are also elevated in early RA, then it is important to determine the suspect diagnosis and treatment guidelines for RA patients. The serum level of SIL-2Rα in patients with RA who can not be diagnosed at first visit was measured experimentally, and the changes of patients’ condition were observed later. To study the relationship between the SIL-2Rα concentration and the condition one year after initial diagnosis.