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目的探讨幽门螺杆菌(Helicobacter pylori,H.pylori)感染与冠心病患者冠状动脉病变程度和血清Ghrelin/obestatin比值之间的关系。方法选取2013年1月至2014年10月行冠状动脉造影确诊冠心病患者116例作为冠心病组,选取同期健康体检人员80例作为对照组。对所有患者的冠状动脉病变程度进行Gensini评分,运用14 C尿素呼气试验方法测定H.pylori感染情况,测定血清Ghrelin和obestatin水平,分析H.pylori感染与冠状动脉病变程度、血清Ghrelin/obestatin比值之间的关系。结果冠心病组H.pylori感染阳性率明显高于对照组,差异有统计学意义(P<0.05)。H.pylori感染阳性组Gensini积分明显高于H.pylori感染阴性组,差异有统计学意义(P<0.05);H.pylori感染阳性组Ghrelin/obestatin比值明显低于H.pylori感染阴性组,差异有统计学意义(P<0.05)。结论 H.pylori感染能够加重冠心病患者冠状动脉病变程度,引起Ghrelin/obestatin比值异常升降低。H.pylori感染与冠心病发生发展密切相关。
Objective To investigate the relationship between Helicobacter pylori (H.pylori) infection and the severity of coronary artery disease and serum Ghrelin / obestatin in patients with coronary heart disease. Methods From January 2013 to October 2014, 116 patients with coronary heart disease diagnosed by coronary angiography were selected as coronary heart disease group, and 80 healthy subjects were selected as the control group. The severity of coronary lesions was evaluated by Gensini score. The 14 C urea breath test was used to determine H.pylori infection. Serum levels of Ghrelin and obestatin were measured. The relationship between H.pylori infection and coronary artery disease, serum Ghrelin / obestatin ratio The relationship between. Results The positive rate of H.pylori infection in CHD group was significantly higher than that in control group (P <0.05). The Gensini score of H.pylori-positive group was significantly higher than that of H.pylori-negative group (P <0.05), and the ratio of Ghrelin / obestatin in H.pylori-positive group was significantly lower than that of H.pylori-negative group There was statistical significance (P <0.05). Conclusions H.pylori infection can aggravate the degree of coronary artery disease in patients with coronary heart disease and cause abnormal increase or decrease of Ghrelin / obestatin ratio. H.pylori infection is closely related to the occurrence and development of coronary heart disease.