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目的观察贲门癌组织中淋巴管的分布及密度,并探讨其临床意义。方法应用D2-40单克隆抗体通过免疫组化Elivision法检测42例贲门癌手术标本和10例正常贲门黏膜中的淋巴管密度(LVD)。结果贲门癌周边区的LVD显著高于癌中心区及正常黏膜(P<0.05);癌中心区和正常黏膜的LVD差异无统计学意义(P>0.05);癌周边区LVD与肿瘤的淋巴结转移情况差异有统计学意义(P<0.05);癌周边区LVD与患者的性别、年龄、病理类型、肿瘤分化程度以及浸润深度无关(P>0.05);癌中心区LVD与上述病理指标均无关(P>0.05)。结论检测贲门癌组织LVD对了解贲门癌患者病情进展和预后判断具有一定临床意义。
Objective To observe the distribution and density of lymphatic vessels in gastric cardia carcinoma and to explore its clinical significance. Methods D2-40 monoclonal antibody was used to detect the lymphatic vessel density (LVD) in 42 cases of cardia cancer and 10 cases of normal cardia mucosa by immunohistochemical Elivision method. Results The LVD in the peripheral area of cardiac carcinoma was significantly higher than that in the central and normal mucosa (P <0.05). There was no significant difference in the LVD between the central and normal mucosa (P> 0.05) (P <0.05). There was no correlation between the LVD in the peripheral area of the cancer and the patient’s sex, age, pathological type, tumor differentiation and the depth of invasion (P> 0.05) P> 0.05). Conclusions The detection of LVD in cardia cancer has some clinical significance in understanding the progression of disease and prognosis in patients with cardiac cancer.