对肿瘤相关糖抗原进行小的结构修饰有可能发现新的抗肿瘤疫苗。由于硫苷具有对内源性糖苷酶的耐受性和非自身抗原特性,因此用S-连接的糖苷键代替O-连接的糖苷键对糖抗原进行修饰可能导致比天然的o-连接糖抗原更强的免疫原性,并可能刺激产生能够识别天然寡糖的抗体。为达此目的,我们成功完成了一个新的肿瘤相关二糖抗原STn的S-连接类似物的合成。 Small structural modifications of tumor-associated carbohydrate antigens have the potential to find new anti-tumor vaccines. Since glucosidase is endowed with endoglucosidase tolerance and non-self-antigenic properties, the modification of carbohydrate antigens with S-linked glycosidic linkages instead of O-linked glycosidic linkages may result in a decrease of the weight of the native o-linked carbohydrate antigen Stronger immunogenicity, and may stimulate the production of antibodies that recognize natural oligosaccharides. To this end, we successfully completed the synthesis of a novel S-linked analog of the tumor associated disaccharide antigen STn.