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口腔内的金属材料以唾液为电解质,在患者口腔粘膜和金属间产生生物电流,使金属离子被溶解而析出,后被咽下入消化道,吸收,渗进皮肤、粘膜,达诱发浓度时,便可产生扁平苔藓。扁平苦藓的组织病理表现是:表皮肥厚,基底层液状变性,真皮(粘膜固有层)上层带状淋巴细胞浸润。浸润淋巴细胞几乎都是T细胞,而且CD_4~+T细胞占优势。牙科金属材料致敏的扁平苔藓也具同样病理表现。最近,Shihara证明,激活了CD_4~+T细胞,产生IFN-γ,TNF-β,而使表皮产生障碍,引起扁平苔藓样反应。
Oral saliva electrolyte material to produce bioelectric current between the patient's oral mucosa and metal, the metal ions are dissolved and precipitated, after being swallowed into the digestive tract, absorption, infiltration into the skin, mucosa, up to the concentration induced, Can produce lichen planus. The histopathological manifestations of flat bitter moss are: epidermis hypertrophy, basal layer fluid degeneration, dermis (lamina propria) upper ribbon lymphocyte infiltration. Infiltrating lymphocytes are almost all T cells, and CD_4 ~ + T cells predominance. Dental metal sensitized lichen planus also has the same pathological findings. Recently, Shihara proved that activation of CD_4 ~ + T cells, the production of IFN-γ, TNF-β, leaving the epidermis disorder, causing lichen planus response.