慢性皮肤单纯疱疹是单纯疱疹病毒(HSV)在衰弱的宿主体内所产生的一种特殊的临床表现,是以慢性、活动性的、破坏性的皮肤损害为特征,并可发展为播散性的类型,其损害可持续数月。本文报告一例68岁妇女,因进行性加剧的肛周疼痛伴轻度出血,体重减轻及不规则间歇性发热4个月而住院。体检发现从肛周到两侧臀部有一约10厘米大小的溃疡,溃疡周围有明显的红晕,并有脓性渗出。于溃疡边缘取材活检示表皮内水疱,有气球状及网状变性,较多的皮肤棘层松解细胞和包含有“毛玻璃”样核内包涵体的典型的多核巨细胞,提示了疱疹病毒感染的特征。皮损处培养有HSVⅡ型生 Chronic herpes simplex is a special clinical manifestation of herpes simplex virus (HSV) that develops in a weakened host and is characterized by chronic, active, damaging skin lesions that develop into disseminated Type, the damage can last for months. This article reports a 68-year-old woman hospitalized for an episode of perianal pain with mild bleeding, weight loss, and irregular intermittent fever for 4 months. Physical examination found from the perianal to both sides of the buttocks have a size of about 10 cm ulcer, obvious flush around the ulcer, and purulent exudation. Biopsies on the edge of the ulcer showed intraepidermal blisters with balloon-like and reticular degeneration, more acantholytic cells and typical multinucleated giant cells containing inclusions of “ground glass” like nucleus suggesting a herpes virus infection Characteristics. HSV Ⅱ type lesions were cultured at birth