【摘 要】
：
Six new tirucallane-type triterpenoids(1-6),along with ten known triterpenoids,were isolated from methylene chlor-ide extract of the resin of Boswellia carterii Birdw.By the application of the comprehensive spectroscopic data,the structures of the compoun
【机 构】
：
Key Laboratory of Structure-Based Drug Design&Discovery,Ministry of Education,Shenyang Pharmaceutica
论文部分内容阅读
Six new tirucallane-type triterpenoids(1-6),along with ten known triterpenoids,were isolated from methylene chlor-ide extract of the resin of Boswellia carterii Birdw.By the application of the comprehensive spectroscopic data,the structures of the compounds were clarified.The experimental electronic circular dichroism spectra were compared with those calculated,which al-lowed to assign the absolute configurations.Compounds 5 and 6 possesed a 2,3-seco tirucallane-type triterpenoid skeleton,which were first reported.Their inhibitory activity against NO formation in LPS-activated BV-2 cells were evaluated.Compound 9 showed appreciable inhibitory effect,with an IC50 value of 7.58±0.87 pmol L-1.
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