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本文应用酶联免疫吸附法检测实验性单疱角膜炎家兔、单疱角膜炎患者及正常人血清和泪液中抗HSV抗体。结果发现:家兔在角膜初次感染单疱病毒前,血清抗体为阴性,感染后逐渐上升为阳性,再次感染后,抗体上升快,滴度高,在相当长时间内保持在较高水平上。泪液抗体的滴度变化与血清平行但略低。正常人血清抗体阳性率在6个月至5岁的幼儿较低,为45%,5至15岁以上者的阳性率分别为95.7%和97.1%,单疱角膜炎患者血清及泪液抗体阳性率和滴度与正常人无显著差异.
In this paper, anti-HSV antibodies in serum and tear of rabbits with experimental single herpes simplex keratitis, patients with single blister keratitis and normal persons were detected by enzyme-linked immunosorbent assay. The results showed that before the initial corneal infection of herpes simplex virus, the serum antibody was negative, and then gradually rose to positive after infection. After the infection again, the antibody rose rapidly and the titer was high, maintaining a relatively high level for a long time. Tear antibody titer changes parallel with the serum but slightly lower. The positive rate of serum antibody in normal people was lower at 45% for children from 6 months to 5 years old, and was 95.7% and 97.1% respectively for those aged 5 to 15 years. The positive rate of serum and tear antibody in patients with herpes simplexis And titers and no significant difference between normal people.