需要接受机械通气治疗的危重病患者发生应激性溃疡引起上消化道出血的危险性增加。关于H_2组胺受体阻滞剂或细胞保护剂硫糖铝对上消化道出血,呼吸机相关性肺炎和病死率的影响存在争议,作者就此进行了多中心双盲随机对照研究。方法.研究对象为16个ICU中接受机械通气治疗至少48小时以上的患者,剔除入院时 Need to receive mechanical ventilation treatment of critically ill patients with stress ulcer caused by the increased risk of upper gastrointestinal bleeding. On the H 2 histamine receptor blocker or cytoprotectant sucralfate on the upper gastrointestinal bleeding, ventilator-associated pneumonia and mortality is controversial, the authors conducted a multi-center double-blind randomized controlled study. Methods The study population included 16 patients who underwent mechanical ventilation for at least 48 hours in the ICU,