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目的探讨毗咯-咪唑聚酰胺类化合物(PIP)对动脉粥样硬化大鼠肾脏结构和功能的影响。方法 60只动脉粥样硬化大鼠,按照数字随机法分为对照组和观察组,每组30只。对照组大鼠不做任何处理,观察组大鼠则注射PIP化合物。比较两组大鼠的肾脏结构和功能的变化。结果观察组大鼠肾小球肥大明显减轻,系膜基质增生明显减轻,肾小管修复现象明显;观察组大鼠肾脏功能中肾小球硬化指数(GSI)和间质纤维化指数(IF)及转化生长因子-β(TGF-β)的检测结果均显著优于对照组,差异具有统计学意义(P<0.05)。结论 PIP化合物对动脉粥样硬化大鼠肾脏结构和功能无明显不良影响,甚至有改善迹象,应用于人体还需作进一步研究。
Objective To investigate the effect of pyrrolidine-imidazole polyamides (PIP) on the structure and function of kidneys in atherosclerotic rats. Methods Sixty atherosclerosis rats were randomly divided into control group and observation group, with 30 rats in each group. The rats in the control group were treated with no treatment, and the rats in the observation group were injected with PIP compounds. The changes of renal structure and function in the two groups were compared. Results In the observation group, glomerular hypertrophy was significantly reduced, mesangial matrix hyperplasia was significantly reduced, and tubule repair was obvious. The glomerular sclerosis index (GSI) and interstitial fibrosis index (IF) The detection of transforming growth factor-β (TGF-β) was significantly better than the control group, the difference was statistically significant (P <0.05). Conclusion The PIP compound has no adverse effect on renal structure and function in atherosclerotic rats, and even shows signs of improvement. The application of PIP to human body needs further study.