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目的:探讨去氧孕烯炔雌醇片和米非司酮治疗围绝经期功能性子宫出血患者效果及对子宫内膜厚度影响。方法:将70例围绝经期功能性子宫出血患者随机分为观察组和对照组各35例,分别于刮宫术后第5天给予米非司酮及去氧孕烯炔雌醇片口服3个月,观察其疗效。结果:观察组患者治疗3个月后血清FSH、LH、E2水平明显低于治疗前,差异有统计学意义(P<0.05);且观察组患者治疗后血清E2水平明显低于对照组,差异有统计学意义(P<0.05)。观察组患者的平均控制出血时间、平均完全控制止血时间明显优于对照组,治疗有效率也明显高于对照组,差异均有统计学意义(P<0.05)。两组患者治疗3个月后子宫内膜较治疗前明显变薄(P<0.05),且观察组患者改善更明显,差异有统计学意义(P<0.05)。结论:米非司酮治疗效果较去氧孕烯炔雌醇片更好,对子宫内膜增长抑制作用更强。
Objective: To investigate the effects of deoxygregate ethinyl estradiol tablets and mifepristone on patients with functional uterine bleeding in perimenopausal period and its effect on the thickness of endometrium. Methods: Seventy patients with functional uterine bleeding in the climacteric period were randomly divided into observation group (35 cases) and control group (35 cases). Three days after the curettage, mifepristone and ethinyl estradiol Month, observe its efficacy. Results: The levels of serum FSH, LH and E2 in observation group were significantly lower than those before treatment (P <0.05), and the serum E2 level in observation group was significantly lower than that in control group after treatment There was statistical significance (P <0.05). The average control bleeding time in the observation group was significantly better than that in the control group, and the treatment effective rate was also significantly higher than that in the control group. The difference was statistically significant (P <0.05). Three months after treatment, the endometrium of the two groups was significantly thinner than that before treatment (P <0.05), and the improvement of the observation group was more obvious with significant difference (P <0.05). CONCLUSION: Mifepristone treatment is better than deoxygregate ethinyl estradiol tablets and has a stronger inhibitory effect on endometrial growth.