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目的:观察蝮蛇咬伤患者凝血功能的变化情况和自制中药(外用蛇肿散及内服蛇毒消)对其的影响。方法:把93例蝮蛇咬伤患者,随机分为两个组,治疗组47例,对照组46例,均给予常规治疗,治疗组加服中药蛇毒消,均以7天为1个疗程。分别于治疗前及治疗后1天、3天、7天抽血观察并比较两组患者凝血功能指标(PT、TT、APTT、FIB、DD、PLT)的变化情况。结果:入院治疗前和治疗1天后两组凝血功能变化无明显差异性;治疗3天后,两组FIB、TT比较具有明显差异性(分别为P<0.05,P<0.05),其他指标两组比较无明显差异性;治疗7天后,两组指标FIB、TT比较具有明显差异性(分别为P<0.01,P<0.05),其他指标两组比较无明显差异性。结论:蝮蛇咬伤患者的凝血功能指标FIB、TT变化明显,中药能明显减轻蝮蛇咬伤患者凝血功能异常。
Objective: To observe the changes of coagulation function in patients with viper snake bites and the effect of self-made traditional Chinese medicine (external use of snake swelling and internal use of snake venom consumption). Methods: 93 cases of viper snake bite patients were randomly divided into two groups, the treatment group 47 cases, the control group 46 cases, were given conventional treatment, the treatment group plus Chinese snake venom consumption, both 7 days for a course of treatment. The changes of coagulation parameters (PT, TT, APTT, FIB, DD, PLT) were observed and compared before treatment, 1 day, 3 days and 7 days after treatment. Results: Before and 1 day after treatment, there was no significant difference in coagulation function between the two groups. After 3 days of treatment, there were significant differences in FIB and TT between the two groups (P <0.05, P <0.05, respectively) There was no significant difference between the two groups after 7 days of treatment. There was significant difference between the two groups in FIB and TT (P <0.01, P <0.05, respectively). There was no significant difference in other indexes between the two groups. Conclusion: The changes of coagulation index FIB and TT in viper snakebite patients are obvious. Chinese medicine can obviously reduce the coagulation dysfunction in viper snakebite patients.