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目的探讨吡格列酮联合二甲双胍治疗2型糖尿病的临床效果。方法选取2014年3月-2016年3月河西区马场街社区卫生服务中心门诊及住院2型糖尿病患者56例,随机分成对照组和观察组,各28例,对照组单用二甲双胍口服控制血糖,观察组口服吡格列酮联合二甲双胍控制血糖,观察两组患者的空腹血糖(FBG)、餐后2 h血糖(2 hBG)、糖化血红蛋白(HbA1c)的变化情况及药物不良反应。结果经过12周治疗,两组患者治疗前后各项临床指标均得到明显改善,观察组和对照组相比临床指标改善情况有明显优势,差异有统计学意义(P<0.05)。结论吡格列酮联合二甲双胍治疗2型糖尿病,效果明显,值得推广。
Objective To investigate the clinical effect of pioglitazone combined with metformin in the treatment of type 2 diabetes mellitus. METHODS: From March 2014 to March 2016, 56 outpatients and inpatients with type 2 diabetes mellitus in Babu Street Community Health Center, Hexi District were randomly divided into control group (28 cases) and observation group (28 cases). The control group received metformin alone to control blood sugar, The observation group was given pioglitazone and metformin orally to control the blood sugar. The fasting blood glucose (FBG), 2 h postprandial blood glucose (2 hBG), HbA1c and adverse drug reactions were observed in two groups. Results After 12 weeks of treatment, the clinical parameters of both groups were significantly improved before and after treatment. There was significant difference between the observation group and the control group in clinical index improvement (P <0.05). Conclusion Pioglitazone and metformin are effective in treating type 2 diabetes mellitus, which is worthy of promotion.