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通过原位共聚制备了一种新型可降解α-磷酸钙/多元氨基酸共聚物复合材料,采用FTIR、XRD、SEM和模拟体液浸泡法对其性能进行表征。结果表明:该复合材料由具有聚酰胺结构的氨基酸共聚物和α-磷酸钙组成;该材料初期降解较快,浸泡1周后材料失重6.8%,12周后材料总失重为20.1%;降解产物无强酸性物质,pH在6.6～7.0范围内;材料吸水率在11%左右,浸泡过程中无明显变化。扫描电镜分析表明,浸泡2周后,材料表面变得光滑,并有少量沉积物生成;随着浸泡时间增加,表面沉积物逐渐增加,12周时大量的沉积物几乎覆盖了样品全部表面。XRD分析表明沉积物为羟基磷灰石,这说明材料具有良好的生物活性;浸泡12周后,去除样品表面沉积物,用XRD分析其直接接触液体的表面和未接触液体的内部表面,发现材料表面的两相结晶峰宽化,而材料内部无显著变化,表明该复合材料可能是一种表面腐蚀降解材料。该新型复合材料可望在骨修复和组织工程方面得到广泛应用。
A novel degradable α-calcium phosphate / polyamino acid copolymer composite was prepared by in-situ copolymerization. The properties of the composites were characterized by FTIR, XRD, SEM and simulated body-fluid immersion. The results showed that the composites consisted of amino acid copolymer with polyamide structure and α-calcium phosphate. The materials were rapidly degraded in the initial stage. After 1 week immersion, the material lost weight 6.8%, and the total weight loss after 20 weeks reached 20.1%. The degradation products No strong acid substances, pH in the range of 6.6 to 7.0; material water absorption of about 11%, no significant changes in the soaking process. Scanning electron microscopy analysis showed that after soaking for 2 weeks, the surface of the material became smooth and a small amount of sediment was formed. As the immersion time increased, the surface sediment increased gradually, and a large amount of sediment almost covered the whole surface of the specimen after 12 weeks. XRD analysis showed that the sediment was hydroxyapatite, indicating that the material has good biological activity; after soaking for 12 weeks, the surface of the sample was removed and analyzed by XRD to directly contact the surface of the liquid and the surface of the liquid which was not in contact with the liquid. It was found that the material The two-phase crystal peak of the surface is broadened, but there is no significant change inside the material, indicating that the composite material may be a surface corrosion degradation material. The new composite material is expected to be widely used in bone repair and tissue engineering.