最近有报道表明,长春烯碱与紫杉醇联合应用能加强长春烯碱对P388鼠白血病的抗肿瘤作用。但是,利用这些药物进行肿瘤联合化疗应当注意在某些条件下这种联合应用可能引起的神经毒性。 5例患者接受隔周1次的长春烯碱加紫杉醇联合化疗。预先静滴地塞米松、苯海拉明及西咪替丁,再静滴长春烯碱20～30mg/m~2,30分钟滴完。然后静滴紫杉醇,剂量为150mg/m~2,给药时间为3小时。这5例患者先前都曾接受过紫杉醇/卡铂化疗,其中1例还加用 Recent reports show that vinorelbine combined with paclitaxel can enhance the anti-tumor effect of vincristine on P388 murine leukemia. However, the use of these drugs in combination with chemotherapy should pay attention to the neurotoxicity that may be caused by such combination under certain conditions. Five patients received once-weekly vincristine plus paclitaxel plus chemotherapy. Premedication of dexamethasone, diphenhydramine and cimetidine, and then intravenous vinylene 20 ~ 30mg / m ~ 2, 30 minutes drip finished. Then intravenous paclitaxel, a dose of 150mg / m ~ 2, dosing time of 3 hours. These 5 patients had previously received paclitaxel / carboplatin chemotherapy, of which 1 case also added