论文部分内容阅读
1999～2004年间,在Norfolk和Norwich大学医院确证有25例患者出现甲氨蝶呤相关的全血细胞减少症,其中11例还服用了叶酸,1例加服了亚叶酸。服用甲氨蝶呤的中值剂量是12.5 mg/周,平均疗程为36个月。全血细胞减少症的严重程度与剂量相关(P<0.05)。有潜在致病风险的患者数量是:肾功能不全者8例;曾有叶酸缺乏者7例;年龄75岁以上者15例;低白蛋白血症患者18例;曾患人工髋关节感染者1例;可能存在药物相互作用18例;剂量错误1例;
Methotrexate-related pancytopenia was confirmed in 25 of the 25 patients in Norfolk and Norwich University Hospitals between 1999 and 2004, with folic acid in 11 and leucovorin in 1. The median dose of methotrexate was 12.5 mg / week with an average of 36 months. The severity of pancytopenia was dose-related (P <0.05). The number of patients with potential risk of disease was: 8 cases of renal insufficiency; 7 cases of folic acid deficiency; 15 cases of patients over 75 years of age; 18 cases of hypoalbuminemia; patients with hip infection 1 Cases; there may be drug interactions in 18 cases; dose error in 1 case;