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[目的]探讨肺结核病人的的免疫功能变化,以及相关指标在初复治、菌阴阳组之间是否存在差异。[方法]采用流式细胞术检测外周血B细胞、T细胞亚群、NK细胞以及采用免疫透射比浊法测定IgG、IgA、IgM。[结果]肺结核患者与正常人相比,CD4+T细胞、CD8+T细胞,CD4/CD8、IgG差异有统计学意义;初治菌阳组与正常对照组相比较,CD4+T细胞、CD4/CD8的差异有统计学意义;初复治对CD4+T细胞计数的影响有统计学意义。菌阴阳对各指标之间差异无统计学意义。[结论]CD4+T细胞对肺结核病人的预后有重要的影响。CD8+T细胞及体液免疫在肺结核的细胞免疫功能中发挥重要作用。
[Objective] To investigate the changes of immune function in patients with pulmonary tuberculosis, and whether there are any differences in the index of initial treatment and the group of yin and yang. [Methods] The peripheral blood B cells, T lymphocyte subsets and NK cells were detected by flow cytometry and IgG, IgA and IgM were determined by immunoturbidimetry. [Results] The difference of CD4 + T cells, CD8 + T cells, CD4 / CD8 and IgG in tuberculosis patients was statistically significant compared with that in normal people. Compared with normal control group, the positive rate of CD4 + T cells, CD4 / CD8 difference was statistically significant; early treatment of CD4 T cell counts had a statistically significant effect. Bacteria yin and yang differences between the various indicators was not statistically significant. [Conclusion] CD4 + T cells have an important impact on the prognosis of patients with pulmonary tuberculosis. CD8 + T cells and humoral immunity play an important role in the cellular immune function of pulmonary tuberculosis.