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为探讨 survivin 基因表达与大肠癌生物学行为及预后的关系,应用免疫组织化学技术(SP 法)检测survivin 基因在20例正常大肠组织、23例结肠腺瘤样息肉及61例大肠癌中的表达。结果表明,survlvin 基因在正常大肠组织中不表达;在大肠癌组织中阳性率是73.8%(45/61);结肠腺瘤样息肉中阳性率为47.8%(11/23),两者间差异有显著意义(P<0.05)。survivin 基因表达与大肠癌的 Dukes 分期、分化程度呈正相关(P<0.05)。survivin 基因蛋白表达阳性者术后3年生存率(26.7%)与阴性者(62.5%)比较,差异有显著意义(P<0.05)。结论:survivin 基因表达发生在大肠癌恶性转化的早期。survivin蛋白的检测可作为大肠癌预后判断的一个重要指标。
To investigate the relationship between survivin gene expression and biological behavior and prognosis of colorectal cancer, the expression of survivin gene was detected by immunohistochemistry (SP method) in 20 cases of normal colorectal tissue, 23 cases of adenomatous polyps and 61 cases of colorectal carcinoma . The results showed that the survivin gene was not expressed in normal colorectal tissues, the positive rate was 73.8% (45/61) in colorectal carcinoma, and the positive rate was 47.8% (11/23) in colonic adenoma. The difference between the two Significant (P <0.05). The survivin gene expression was positively correlated with the Dukes stage and differentiation of colorectal cancer (P <0.05). Survivin gene protein positive expression of postoperative 3-year survival rate (26.7%) and negative (62.5%), the difference was significant (P <0.05). Conclusion: Survivin gene expression occurs in the early stage of malignant transformation of colorectal cancer. The detection of survivin protein can be used as an important indicator of the prognosis of colorectal cancer.