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采用纯系大鼠正位穿透性角膜移植动物模型,研究了结膜下注射FK506对一眼角膜移植免疫排斥后另眼高危移植排斥的防治效果。结果显示,FK506能显著地延长植片的存活时间。认为:对于以往有移植失败的高危病例,尽早应用有效的免疫抑制剂十分必要。
The pure rat anterior penetrating keratoplasty animal model was used to study the effect of subconjunctival injection of FK506 on the prevention and treatment of other high-risk rejection following corneal graft rejection. The results show that FK506 can significantly prolong the survival time of the implants. It is considered that it is necessary to apply effective immunosuppressive agents as soon as possible for high-risk cases that have failed to transplant in the past.