论文部分内容阅读
用1,2-二甲基肼(D.M.H)诱发的大鼠结肠腺癌γ-谷酰胺转移酶(γ-GT)活性比正常成年大鼠的高6～7倍,在胚胎或新生大鼠结肠中γ-GT的水平几乎与腺癌一样高。D M.H诱发的肿瘤与人的结肠腺癌极为相似,所以作者希望借此研究人类结肠腺癌是否可用γ-GT活性增加来区别正常的同种组织。人类结肠肿瘤切除后的新鲜标本冰冻切片进行γ-GT组织化学反应,证明瘤组织内确含有集聚的γ-GT,与正常组织相联处的γ-GT限于柱状上皮的外层。一例57岁升结肠腺癌合饼持续性直肠出血的患者,瘤细胞γ-GT强阳性,而邻近肿瘤的正常组织γ-GT阴性。人结肠癌与大鼠结肠腺癌的发生可能相似,作者发现人类结肠癌前期γ-GT活性增加和D.M.H诱
Rat gamma-glutamyltransferase (γ-GT) activity induced by 1,2-dimethylhydrazine (DMH) is 6-7 times higher than that of normal adult rats, in the colon of embryonic or neonatal rats The level of gamma-GT is almost as high as that of adenocarcinoma. The D M.H-induced tumor is very similar to human colon adenocarcinoma, so the authors hope to study whether human colon adenocarcinoma can use γ-GT activity to differentiate normal normal tissue. The gamma-GT histochemical reaction was performed on frozen sections of fresh specimens after removal of human colon tumors. It was confirmed that the tumor tissues contained aggregated γ-GT, and the γ-GT at the junction with normal tissues was limited to the outer layer of the columnar epithelium. In a 57-year-old patient with ascending colon rectal adenocarcinoma and persistent cake bleeding, γ-GT was strongly positive in tumor cells, whereas γ-GT was negative in normal tissues adjacent to tumors. Human colon cancer may be similar to colon adenocarcinoma in rats. The authors found that gamma-GT activity in premenopausal human colon cancer increased and D.M.H induced