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据估计,1～3％的儿童白血病是慢性粒细胞性白血病(CGL)。儿童CGL有两类:Ph~1阳性型类似于成人,而Ph~1阴性型(幼稚型)的特点为皮疹,感染,血小板减少,对化疗的抗药性及胎儿血红蛋白增加。作者两年内发现123例白血病新患者中Ph~1阳性型的白血病有8例(6.5％)。对这些病人的临床、形态学、细胞遗传学及免疫学特征加以论述,并且提出儿童Ph~1阳性型白血病比以往所认识的更为常见,且其临床表现也更加不同。本文报道的123例儿童白血病中,Ph~1
It is estimated that 1 to 3% of children with leukemia is chronic myelogenous leukemia (CGL). There are two types of CGL in children: Ph~1 positive type is similar to adults, and Ph~1 negative type (naive type) is characterized by rash, infection, thrombocytopenia, resistance to chemotherapy, and increased fetal hemoglobin. Within two years, the author found that there were 8 cases (6.5%) of Ph 1 positive leukemia in 123 new leukemia patients. The clinical, morphological, cytogenetic and immunological characteristics of these patients were discussed, and it was proposed that children with Ph 1 positive leukemia are more common than previously known, and their clinical manifestations are even more different. This article reports 123 children with leukemia, Ph~1