论文部分内容阅读
目的探讨急性脑卒中患者血清三碘甲状腺原氨酸(T3)与病情严重程度的相关性。方法回顾性分析2012年9月至2015年12月收治该院神经内科的80例急性脑卒中伴低T3且经综合治疗后病情有好转的患者,其中出血性脑卒中43例(出血量≥30 ml 20例,<30 ml 23例),缺血性脑卒中患者37例(梗死面积≥20 cm~2 18例,<20 cm~2 19例),80例患者依据美国国立卫生研究院卒中量表(NIHSS)评分分为中重度组脑卒中患者36例,轻度组脑卒中患者44例;监测自入院第1、21天治疗前后T3水平,同期进行NIHSS评分(第21天较第1天NIHSS评分有下降)。设门诊健康对照组50例。结果出血量≥30 ml的患者T3水平为(0.334±0.192)ng/ml,<30 ml患者T3水平为(0.423±0.187)ng/ml,差异显著(P<0.05)。梗死面积≥20 cm~2的患者T3水平为(0.391±0.189)ng/ml,<20 cm~2患者T3水平为(0.513±0.178)ng/ml,差异显著(P<0.05)。急性脑卒中患者T3水平较对照组均明显降低,且中重度组低于轻度组,治疗前低于治疗后(P<0.05)。结论急性脑卒中患者的血清甲状腺激素水平与病情严重程度有明显相关性,动态监测T3有助于急性脑卒中的预后评估。
Objective To investigate the relationship between serum triiodothyronine (T3) and severity of illness in patients with acute stroke. Methods A retrospective analysis of 80 patients with acute stroke with low T3 admitted to the department of neurology from September 2012 to December 2015 in our hospital was performed. The patients had improvement after treatment, of which 43 were hemorrhagic stroke (bleeding ≥30 ml in 20 cases, and <30 ml in 23 cases), ischemic stroke in 37 cases (infarcted area ≥20 cm ~ 2 18 cases, <20 cm ~ 219 cases) and 80 patients according to the National Institutes of Health Stroke NIHSS scores were divided into moderate and severe group of stroke patients 36 cases, mild group of stroke patients 44 cases; monitoring since hospital admission day 1,21 days before and after treatment T3 levels NIHSS score (21 days compared with the first day NIHSS score has dropped). Outpatient health control group of 50 cases. Results The T3 level was (0.334 ± 0.192) ng / ml in patients with bleeding> 30 ml, and (0.423 ± 0.187) ng / ml in <30 ml patients (P <0.05). T3 level was (0.391 ± 0.189) ng / ml in patients with infarction area≥20 cm ~ 2, and (0.513 ± 0.178) ng / ml in patients under 20 cm ~ 2, with significant difference (P <0.05). T3 levels in patients with acute stroke were significantly lower than those in the control group, and moderate to severe group was lower than mild group, before treatment was lower than after treatment (P <0.05). Conclusion Serum thyroid hormone levels in patients with acute stroke are significantly correlated with the severity of the disease. Dynamic monitoring of T3 contributes to the prognosis assessment of acute stroke.