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为了解肝脏促癌剂微囊藻毒素(MC)在肝癌高发区饮用水中的污染情况,于1992至1993年对江苏海门居民饮用水中藻类及其产生的MC进行了检测,经鉴定在海门沟河水中颤藻是目前已被证明能产生MC的最常见的藻属;在65个水样中有2份经高效液相和液相色谱/质谱分析确定含有MC。进一步于1994年7月在江苏海门采集不同饮用水源共989份,采用高敏感度酶联免疫方法测定MC含量。结果在沟塘水、河水、浅井水和深井水中MC的阳性率(>50pg/ml)分别为17.3%,31.9%,4.3%,0.0%;阳性样本中MC平均含量分别为101,160,68,0。在沟塘水和河水中MC的阳性率和阳性样本中的平均含量均显著大于浅井水和深井水,提示应对饮用水中MC与肝癌的关系作进一步研究。
In order to understand the contamination of the liver cancer promoting agent microcystin (MC) in drinking water in high-risk areas of liver cancer, the algae in drinking water of Haimen residents in Jiangsu Province were detected from 1992 to 1993, and were identified in Haimen. Stellar algae in the gully river is the most common algae species that have been shown to produce MC; 2 of the 65 water samples were determined to contain MC by HPLC and LC/MS analysis. In July 1994, a total of 989 different drinking water sources were collected in Haimen, Jiangsu, and the MC content was determined by high-sensitivity enzyme-linked immunosorbent assay. Results The positive rates of MC in ditch and pond water, river water, shallow well water and deep well water (>50pg/ml) were 17.3%, 31.9%, 4.3% and 0.0%, respectively; The contents were 101, 160, 68, 0, respectively. The positive rate of MC in the ditch and river water and the mean content in the positive samples were significantly greater than those in the shallow wells and deep wells, suggesting that the relationship between MC and liver cancer in drinking water should be further studied.