细胞内钙离子是绝大多数细胞激素释放所必需的,它在胰岛素的分泌过程中也起着重要作用,通过生物电,电镜和放射性同位素等方法对钙离子在胰岛素释放过程中的作用已进行了详细的研究。胰岛素的分泌过程是由细胞质中钙离子的积聚触发的,即所谓的“刺激—分泌偶联”。然而,在离体研究中发现钙离子本身并不能引起胰岛B细胞释放胰岛素,但在葡萄糖和其它促分泌素刺激的胰岛素分泌反应中,钙离子是促进胰岛素分泌所必需的。 Intracellular calcium ion is required for most cytokines release and plays an important role in insulin secretion. The effect of calcium ion in insulin release process has been carried out by bioelectricity, electron microscope and radioactive isotope A detailed study. Insulin secretion is triggered by the accumulation of calcium ions in the cytoplasm, the so-called “stimulus-secretion coupling.” However, it has been found in an in vitro study that calcium ion alone does not cause islet B cells to release insulin, but calcium is necessary for the promotion of insulin secretion in glucose and other secretagogue-stimulated insulin secretion reactions.