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目的利用基于体素的形态学(voxel-basedmorphometry,VBM)比较,探讨弱视儿童中灰质发育的异常。方法13例弱视儿童和14例视力正常儿童进行了3DT1WI扫描,数据在SPM2下进行头颅标准化、分割、平滑的后处理后,对病例组和对照组的数据进行归一化处理,将体素内的信号转换为灰质密度的差别,以双样本独立t检验进行病例组和对照组的基于体素的灰质密度比较,分析弱视患者灰质病变的区域。结果弱视组和对照组的左侧额中回,海马旁回和梭状回,颞下回和双侧距状回的灰质密度差异具有统计学意义,P<0.001。这些区域的体素数目从12个至36个不等。结论基于体素的形态学研究能够发现弱视儿童中与视觉相关的大脑区域的灰质发育异常,从而为探讨引起弱视的神经结构发育异常提供了有用的信息。
Objective To investigate the abnormalities of gray matter development in children with amblyopia using voxel-based morphometry (VBM). Methods Thirteen children with amblyopia and 14 children with visual acuity were scanned with 3DT1WI. The data were normalized, segmented and smoothed in SPM2. The data of case group and control group were normalized, Signal to gray matter density, and voxel-based gray matter density was compared between the case group and the control group by two-sample independent t-test to analyze the gray matter lesions in amblyopic subjects. Results The differences in gray matter densities between the left frontal gyrus, the parahippocampal gyrus, the fusiform gyrus, the inferior temporal gyrus and the bilateral dorsal gyrus in the amblyopic group and the control group were statistically significant (P <0.001). The number of voxels in these regions ranged from 12 to 36. Conclusions Voxel-based morphological studies can reveal gray matter dysplasia in visual-related brain regions of children with amblyopia and thus provide useful information for exploring the neurodevelopmental abnormalities that cause amblyopia.