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为探讨下咽癌中P~(53)基因突变的规律与特征,采用PCR—SSCP方法检测40例下咽癌新鲜手术标本组织,分析P~(53)基因突变与下咽癌有关病理指标的关系。40例下咽癌有28例(70％)出现P~53基因第5～8外显子突变。P~(53)基因突变与下咽癌TNM分期、病理分级及淋巴结转移密切相关(P<0.05)。结果显示P~(53)基因突变与下咽癌的生物学行为有关且具有预后价值。
In order to investigate the regularity and characteristics of P53 mutation in hypopharyngeal carcinoma, PCR-SSCP method was used to detect 40 cases of fresh surgical specimens of hypopharyngeal carcinoma and analyze the pathological parameters of P53 mutation and hypopharyngeal carcinoma. relationship. Forty cases of hypopharyngeal carcinoma (70%) showed mutations in exon 5-8 of P53 gene. P53 mutation was closely related to TNM staging, pathological grade and lymph node metastasis of hypopharyngeal carcinoma (P<0.05). The results showed that P53 mutations are related to the biological behavior of hypopharyngeal carcinoma and have prognostic value.