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目的：探讨表皮生长因子受体（ＥＧＦＲ）在中耳胆脂瘤发生，发展中的作用。方法：运用免疫组化方法检测表皮生长因子受体在１０例正常外耳道上皮及３６例胆脂瘤上皮中的表达情况。结果：１０例正常外耳道上皮全部为阴性，３６例胆脂瘤上皮中２３例出现ＥＧＦＲ阳性表达（阳性率为６３．９％）ＥＧＦＲ阳性表达与中耳胆脂瘤骨质破坏程度呈正相关。结论：ＥＧＦＲ过度表达与胆脂瘤上皮细胞增生及胆脂瘤周围骨质破坏有关，它在胆脂瘤的发生、发展中起着重要作用。
Objective: To investigate the role of epidermal growth factor receptor (EGFR) in the development of middle ear cholesteatoma. Methods: Immunohistochemistry was used to detect the expression of epidermal growth factor receptor in 10 cases of normal external auditory canal epithelium and 36 cases of cholesteatoma epithelium. RESULTS: All 10 cases of normal external auditory canal epithelium were negative. EGFR positive expression was found in 36 cases of cholesteatoma epithelium (positive rate was 63.9%). Positive expression of EGFR was positively correlated with bone destruction of middle ear cholesteatoma. Conclusion: Overexpression of EGFR is associated with hyperplasia of cholesteatoma epithelial cells and destruction of bone around cholesteatoma. It plays an important role in the occurrence and development of cholesteatoma.