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目的研究脑缺血再灌注后脑电功率参数变化与缺血损伤的关系。方法沙土鼠全脑缺血再灌注模型，分为假手术组、对照组和山莨菪碱组，观察边缘频率（ＳＥＦ）、双谱指数（ＢＩＳ）和α、β、δ、θ波比率的变化，以海马ＣＡ１区锥体细胞坏死的数目来判断脑缺血损伤的严重程度。结果脑缺血再灌注后，对照组δ波比率增高至缺血前的２１３％，α波比率降低至缺血前的２６％（Ｐ＜０．０１）。山莨菪碱组δ波比率增高至缺血前的１４１％，α波比率降低至缺血前的９０％，其增高和降低的程度明显小于对照组（Ｐ＜０．０５）。山莨菪碱组海马ＣＡ１区坏死的锥体细胞数目也少于对照组。结论脑缺血再灌注期间δ波比率增高可能为存在严重脑缺血损伤的标志之一。
Objective To study the relationship between changes of brain electrical parameters and ischemia injury after cerebral ischemia-reperfusion. Methods The global cerebral ischemia-reperfusion model in gerbils was divided into sham operation group, control group and anisodamine group. The changes of marginal frequency (SEF), bispectral index (BIS) and α, β, δ, , The number of pyramidal cells in hippocampal CA1 area to determine the severity of cerebral ischemic injury. Results After cerebral ischemia / reperfusion, the δ wave ratio in the control group increased to 213% before ischemia and the α wave ratio decreased to 26% before ischemia (P <0.01). In the anisodamine group, the δ wave ratio increased to 141% before ischemia and the α wave ratio decreased to 90% before ischemia, which was significantly lower than that in the control group (P <0.05). Anisodamine group of hippocampal CA1 area necrosis of the number of pyramidal cells is also less than the control group. Conclusion The increased δ-wave ratio during cerebral ischemia-reperfusion may be one of the markers of severe cerebral ischemia.