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给狗静脉输注含硫酸镁生理盐水,肺体循环的阻力及压力均呈剂量依赖性降低,输注Mg-SO_4 4 mg/(kg.min)30 min后,肺血管阻力由给药前的 93.0±5.7降至 76.5±6.5 kPa·s~(-1)/L,体血管阻力则由 938.0±53.0降至 791.0±79.0 kPa·s~(-1)/L;并伴有动脉血浆TXB_2 浓度下降。硫酸镁还可抑制缺氧性肺血管收缩反应(HPV),输注 MgSO_4 1 mg/(kg.min)30 min后虽然基础 PVR无变化,但缺氧所致△PVR％降至18.2±8.5％,明显低于给药前(40.1±8.4％);但对动脉血浆6-酮(keto)-PGF_(1α)及TXB_2 变化无影响。腺苷降低肺、体血管阻力,但因心输出量增加使肺动脉压升高;腺苷对HPV没有影响。
After intravenous infusion of magnesium sulfate-containing saline, resistance and pressure of the pulmonary circulation decreased in a dose-dependent manner. After infusion of Mg-SO 4 4 mg / (kg · min) for 30 min, pulmonary vascular resistance decreased from 93.0 ± 5.7 to 76.5 ± 6.5 kPa · s -1 / L and body vascular resistance decreased from 938.0 ± 53.0 to 791.0 ± 79.0 kPa · s -1 / L, accompanied by a decrease in TXB 2 concentration in arterial plasma . Magnesium sulfate also inhibited hypoxic pulmonary vasoconstriction (HPV). After infusion of MgSO_4 at 1 mg / (kg · min) for 30 min, although PVR did not change, the △ PVR% of hypoxia dropped to 18.2 ± 8.5% , Which was significantly lower than that before administration (40.1 ± 8.4%), but had no effect on the change of keto-PGF_ (1α) and TXB_2 in arterial plasma. Adenosine reduces lung and body vascular resistance, but increased cardiac output due to increased pulmonary artery pressure; adenosine has no effect on HPV.