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目的探讨在综合治疗感染性休克的过程中患者体内CRP与PCT的含量变化情况。方法以感染性休克患者40例为观察组,非感染性休克者40例为对照组。观察组采用恰当的液体复苏并进行抗感染性休克综合治疗。采集对照组和观察组患者治疗过程中(0、3、6、12、24、36、48、72 h)静脉血液,测定血样中CRP、PCT的含量。结果观察组患者各时间点的血清中CRP、PCT含量均高于对照组,两组之间的差异具有统计学意义(P<0.05);随着治疗时间的延长及患者病情的好转,观察组患者血清中CRP、PCT含量均明显下降;观察组患者各时间点血清中CRP含量之间的差异均有统计学意义(P<0.05);观察组患者各时间点血清中PCT含量之间的差异均有统计学意义(P<0.05)。结论患者血清中CRP、PCT含量与患者体内感染程度及疾病发展密切相关,可用于监测患者病情变化,指导临床治疗。
Objective To investigate the changes of CRP and PCT in patients with septic shock during the comprehensive treatment of septic shock. Methods Forty patients with septic shock were selected as the observation group, and 40 patients with non-septic shock as the control group. The observation group used the appropriate liquid resuscitation and anti-infective shock comprehensive treatment. Venous blood was collected during the treatment (0, 3, 6, 12, 24, 36, 48, 72 h) in the control group and the observation group, and the contents of CRP and PCT in the blood samples were determined. Results The serum levels of CRP and PCT in the observation group were higher than those in the control group at each time point. The difference between the two groups was statistically significant (P <0.05). With the prolongation of treatment time and the improvement of the patients’ condition, the observation group The levels of CRP and PCT in serum of patients were significantly decreased. The differences of CRP levels in serum of patients in observation group at each time point were statistically significant (P <0.05). The difference of PCT content in serum of patients in observation group at different time points All were statistically significant (P <0.05). Conclusions Serum levels of CRP and PCT are closely related to the degree of infection in the patient and the development of the disease, and can be used to monitor the patient’s condition and guide the clinical treatment.