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目的:探讨急性冠脉综合征患者治疗前后血浆PAF、TPO水平变化及临床意义。方法:急性冠脉综合征65例为观察组,采用酶联免疫吸附试验测定治疗前、后血浆PAF、TPO水平,正常对照组29例。结果:急性心肌梗死患者、不稳定型心绞痛组治疗前,血浆PAF水平分别为(125.56±19.72)μg/L、(117.32±23.88)μg/L,健康对照组为(61.10±17.80)μg/L,观察组治疗后下降,均为P<0.01;急性心肌梗死患者、不稳定型心绞痛组血浆TPO水平,治疗前分别为(57.16±22.80)ng/L、(32.07±14.20)ng/L,均高于健康对照组(19.72±16.96)ng/L,P<0.01,观察组治疗后下降。结论:急性冠脉综合征患者血浆PAF水平和TPO水平升高,是反映与血小板功能和活化状态相关的非特异性炎症标志物,可以观察疗效。
Objective: To investigate the changes of PAF and TPO levels in patients with acute coronary syndrome before and after treatment and their clinical significance. Methods: 65 cases of acute coronary syndrome were selected as the observation group. The levels of PAF and TPO in plasma before and after treatment were measured by enzyme-linked immunosorbent assay (ELISA) in 29 cases of normal control group. Results: The levels of plasma PAF in patients with acute myocardial infarction before and after treatment were (125.56 ± 19.72) μg / L and (117.32 ± 23.88) μg / L, respectively, and those in the healthy control group were (61.10 ± 17.80) μg / L (P <0.01). The levels of TPO in patients with acute myocardial infarction and unstable angina were (57.16 ± 22.80) ng / L and (32.07 ± 14.20) ng / L before treatment Higher than the healthy control group (19.72 ± 16.96) ng / L, P <0.01, the observation group decreased after treatment. Conclusion: PAF levels and TPO levels in patients with acute coronary syndrome are nonspecific inflammatory markers that reflect platelet function and activation status, and the curative effect can be observed.